Calcium Carbonate + Zinc + Calcitriol Tablets

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Therapeutic Indication

Prevention and treatment of low calcium levels
Calcitriol improves calcium absorption and corrects deficiency
Supports immune function, wound healing, and growth
Helps prevent and manage bone loss
Treats softening of bones due to deficiency
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Calcium Carbonate + Zinc + Calcitriol

Tablet

This is a combination of Calcitriol, elemental Calcium which is derived from Calcium Carbonate (from Oyster shell) and elemental Zinc derived from Zinc Sulphate - which is a perfect synergistic joint- relieving product and helps repair joint damage mostly useful in Osteoporosis and Osteoarthritis. Osteoarthritis is a joint pain inflammation that results from cartilage degeneration and hyperhomocystemia- an independent risk factor for osteoporosis.
Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. Calcitriol is the active form of vitamin D 3 (cholecalciferol).
It is produced in the kidney from the vitamin D metabolite, 25-hydroxyvitamin D3(25(OH) D3 ).
Calcium plays a critical role in the body. It is essential for the normal functioning of nerves, cells, muscle and bone. Calcium prevents bone loss and is associated with a modest reduction in fracture risk. Calcium and vitamin D preparations are used to prevent or to treat calcium deficiency. A vitamin D-resistant state may exist in uraemic patients because of the failure of the kidneys to adequately produce calcitriol.
Zinc is a nutritional supplement important for normal growth and tissue repair. Urinary elimination of zinc is increased in osteoporotic people. Zinc depletion is shown to diminish the response of oral calcitriol when administered orally. Supplementary zinc not only improves calcitriol response but also helps to arrest bone loss in older postmenopausal women.
This is a delicately balanced formula to improve bone and joint health and combating debilitating bone-joint diseases.
Technical functions and advantages of the product:

  • Promotes Cartilage Health and Improves Joint Flexibility and Mobility
  • Maintains calcium level in body
  • Naturally Derived and Clinically Proven Ingredients

Speciality Orthopedics | Endocrinology | Internal Medicine
Tags Bone Health | Calcium Supplement | Vitamin D3 | Osteoporosis
Strength
  • Calcium Carbonate 500 mg
  • Zinc 7.5 mg
  • Calcitriol 0.25 mcg
Packing Size
  • 10 Tablets

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Mechanism

  • Calcitriol: Enhances intestinal absorption of calcium and phosphate; reduces parathyroid hormone secretion.
  • Calcium Carbonate: Provides elemental calcium for bone mineralization, muscle contraction, and nerve conduction.
  • Zinc: Cofactor for enzymes in bone metabolism; supports collagen synthesis and tissue repair.

Pharmacokinetics

  • Absorption: Calcitriol rapidly absorbed; Calcium absorption enhanced in acidic gastric environment; Zinc absorbed in small intestine.
  • Distribution: Calcium stored in bones and teeth; Zinc distributed in muscles and bone; Calcitriol circulates bound to vitamin D-binding protein.
  • Metabolism: Calcitriol metabolized in kidney and liver; Calcium incorporated into bone matrix; Zinc functions as enzyme cofactor.
  • Excretion: Calcitriol via urine; Calcium via urine and feces; Zinc via urine and bile.
  • Half-life: Calcitriol ~5–8 hours; Calcium depends on bone turnover; Zinc variable depending on nutritional status.

Side Effects

  • Mild rash or itching (rare)
  • Hypercalcemia (rare, with prolonged use or overdose)

Contraindication

  • Elevated serum calcium levels
  • Risk of worsening hypercalcemia
  • Reduced clearance of calcium and vitamin D metabolites/7

Interaction

  • Antacids: May reduce absorption of calcium and zinc.
  • Corticosteroids: Increase risk of osteoporosis; supplementation improves outcomes.
  • Bisphosphonates: Calcium interferes with absorption; separate dosing recommended.
  • Iron supplements: High doses compete with zinc absorption.
  • Diuretics: Thiazides increase calcium retention; loop diuretics increase calcium loss.

Warning and Precautions

  • Monitor patients with recurrent kidney stones.
  • Use cautiously in diabetics (D-Mannose may affect glucose metabolism).
  • Not recommended in pregnancy without medical advice.
  • Discontinue if severe gastrointestinal upset occurs.